Cholinergic Drugs – Pharmacology, Animation



(USMLE topics) Mechanisms of action of cholinergic agonists and antagonists (anticholinergics): direct and indirect agonists …

Diploma Sains Para-perubatan

#Cholinergic #Drugs #Pharmacology #Animation

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  • @094ss47ss

    Thank you so much for sharing ❤❤

  • @guibyalknosee234

    Is a chronical cholinergic crisis a possible thing? I'm asking because after just three doses of choline alfoscerate at 400 mg, I developed a bunch of torturous symptoms. For more than six weeks I have been constantly in a depressed, anxious, desperate mood. I have no appetite at all (I hardly can eat), I have ringing in the ears, bradycardia, thready pulse, impaired circulation, increased intestinal peristalsis, fatigue, chills, sweating, slight fever, weakness and other crazy parasympathetic effects. Is it theoretically possible that, for some unknown reason, my acetylcholine level does not decrease and even gradually accumulates, which leads to such symptoms?

    This hypothesis came to my mind for the following reasons:

    1) The antidepressants prescribed to me only affect my mood but have no effect on the "muscarinic" symptoms, like bradycardia. It looks like a mood disorder is one of the manifestations of the disease, and not the disease itself.

    2) Atropine temporarily relieves my condition

    3) A dose not exceeding 1 mg of atropine does not even raise my pulse

    4) Over time, the effectiveness of atropine decreases. Since I use it only in extreme cases, my body's adaptation to it is doubtful.

    5) If acetylcholine does not accumulate in my body, then the disease would go away by itself, since cholinesterase would quickly remove excess acetylcholine

    So how to reduce the level of acetylcholine in my body or, if this is not possible, how to block excess acetylcholine? What medications are best for this?

  • @pragyapathak5168

    Marvelous and too much good this summary . Thanku so much for making this video🙏🙏🙏

  • @HK-mf1ve

    why does acetylcholine (parasympathetic) cause WAKEFULLNESS. Shouldn't it make you sleepy instead?? Instead, it is the ANTI-cholinergics (like diphenhydramine) that make you sleepy. Counter-intuitive?

  • @agglyusr

    wonderful video. thank you.

  • @lowangdragneel5117

    Thanks this one saves a budding cologist who is tryna make everything right for his parents ❤

  • @johnathanabrams8434

    How does that make sense ? Acetylcholine is the primary neurotransmitter of the parasympathetic nervous system….

    During a time of fight or flight ( sympathetic nervous system) acetylcholine leaks from the neuromuscular junction and acetylcholinesterase is inhibited.

    Does the system need more acetylcholine or less ?